botulinum antitoxin การใช้

• HHS also wants to bolster the very small supply of botulinum antitoxin.
• Two preparations of botulinum antitoxins are available for treatment of botulism.
• Trivalent ( A, B, E ) botulinum antitoxin is derived from equine sources using whole antibodies.
• This action left " HBAT " as the only botulinum antitoxin available in the US for naturally occurring non-infant botulism.
• The second antitoxin is Heptavalent ( A, B, C, D, E, F, G ) botulinum antitoxin, which is derived from equine antibodies which have been altered to make them less immunogenic.
• As part of a $ 450 million contract with BARDA for the SNS, Emergent also developed the only FDA-licensed botulinum antitoxin, BAT [ Botulism Antitoxin Heptavalent ] for treating naturally occurring botulism . [ v ] Canada has also approved BAT.
• In 2010, the CDC replaced the licensed bivalent botulinum antitoxin AB ( " BAT-AB ", or  BabyBIG ) and the investigational monovalent botulinum antitoxin E ( " BAT-E " ) with " HBAT " when the former two products indications expired.
• In 2010, the CDC replaced the licensed bivalent botulinum antitoxin AB ( " BAT-AB ", or  BabyBIG ) and the investigational monovalent botulinum antitoxin E ( " BAT-E " ) with " HBAT " when the former two products indications expired.
• Trivalent ( A, B, E ) botulinum antitoxin is derived from equine sources utilizing whole heptavalent ( A, B, C, D, E, F, G ) botulinum antitoxin, is derived from " despeciated " equine IgG antibodies which have had the Fc portion cleaved off leaving the F ( ab') 2 portions.
• Trivalent ( A, B, E ) botulinum antitoxin is derived from equine sources utilizing whole heptavalent ( A, B, C, D, E, F, G ) botulinum antitoxin, is derived from " despeciated " equine IgG antibodies which have had the Fc portion cleaved off leaving the F ( ab') 2 portions.